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KMID : 0382419980240030018
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Korean Journal of Environmental Health Society
1998 Volume.24 No. 3 p.18 ~ p.21
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Effect of Brief Treatment of Bromobenzene on the Liver Na+ / K+ - ATPase Activity in Rats
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Yoon Chong-Guk
Chae Soon Nim
Shin Joong-Kyu
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Abstract
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To evaluate an effect of brief treatment of bromobenzene on the liver Na^+/K^+-ATPase activity, the single dose of bromobenzene (400 mg/kg body weight, i.p.) was injected to the rats and then sacrificed at 4 hrs after treatment.
The bromobenzene-treated animals showed more increased liver weight per body weight(%) and decreased hepatic protein content than control group. At the same time serume alanine aminotransferase (ALT) activity was tend to increase but it did not mean statistical significance.
The animals showed a tendency of increased content of hepatic cytochrome P-450 and decreased GSH content by the bromobenzene treatment.
On the other hand, injection of bromobenzene to the rats showed significantly increased activity(p<0.05) of liver Na^+/K^+-ATPase activity compared with control.
Concomitantly in the enzyme preparation of pooled liver homogenate, Km value in bromobenzene-treated rats was similar with the control, but V_max was 1.5 fold increased in bromobenzene-treated rats compared to the control.
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